Welcome to
TopMatch
TopMatch calculates the similarity of protein structures.

TopMatch can be used for single protein chains and multichain complexes.

For a quick start, here are some examples you can try upon your first visit:

  
Single protein chainsHuman hemoglobin and neuroglobin
(140 + 150 residues)
Crystallographic asymmetric unitsHistidine-tRNA synthetases
(780 + 840 residues)
Biological assembliesComplete ribosomes
(11.000 + 6.500 residues;
visualization may take some time…)
Query:   or Upload CIF file 
 
Target: 
For more information on input and results, please see TopMatch's help page.
If you find TopMatch useful for your research, please cite the following reference:
Sippl & Wiederstein (2012).
Detection of correlations in protein structures and molecular complexes.
Structure 20, 718-728. image
The previous version of TopMatch-web is still available but will be retired soon.